Vol.101 No.11 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 101 No. 11 November 2008
Syndrome of Inappropriate Antidiuretic Hormone Secretion
Following Chemotherapy with Nasopharyngeal Cancer
Hidetake Matsuyoshi and Eiji Yumoto
(Graduate School of Medical Sciences, Kumamoto University)
We report a 51-year-old male with nasopharyngeal cancer (T4N2cM1) complicated by syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following cisdichlorodiamimnine platinum (CDDP), Docetaxel, 5-fluororacil (5-FU) administration. After administration of CDDP, Docetaxel and 5-FU, the serum sodium concentration decreased from 137 mEq/l to 117 mEq/l. His consciousness level was JCS (Japan Coma Scale) 30. He was diagnosed as SIADH having based on appropriate diagnostic criteria. The sodium concentration and consciousness level were improved with sodium revision, water restrictions and internal steroid use. We must take symptoms of low sodium blood concentration due to SIADH into consideration, and give sufficient attention to the electrolyte balance after chemotherapy.
Key words :syndrome of inappropriate antidiuretic hormone secretion, nasopharyngeal cancer, CDDP, Docetaxel