Vol.102 No.10 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 102 No. 10 October 2009
Efficancy of Concurrent Chemoradiotherapy in
Advanced Hypopharyngeal Carcinoma
Tsutomu Ueda, Haruo Hirakawa and Hiromi Furuie
(Kure Medical Center and Chugoku Cancer Center)
Concurrent chemoradiotherapy is effective in preserving the hypopharynx in a high percentage of patients, but neck control after concurrent chemoradiotherapy is poor.
We treated 21 patients-18 men and 3 women with a mean age of 60.8 years-for advanced hypopharyngeal carcinoma from 1996 to 2006 using concurrent chemoradiotherapy.
Primary tumor sites included the pyriform sinus in 13, the posterior pharyngeal wall in 3, and postcricoid in 5. Six were stage III and 15 stage IV.
Seventeen had complete response (CR) and 4 partial response (PR). Disease-specific 3-year survival was 60.2％-stage III: 83.3％, stage IV: 62.5％-. Disease-specific 5-year survival was 46.8％-stage III: 62.5％, stage IV: 39.6％-.
Eighteen of the 21 (85.7％) showed CR at primary, and 14 of 18 node-positive patients (77.8％) showed CR in neck lymph nodes. Recurrence rate at the primary site was 16.7％-3 of 18 CR patients-and 57.1％-8 of 14 CR patients-at neck lymph nodes.
We are now considering planned neck dissection after concurrent chemoradiotherapy to improve neck lymph nodes control.
Key words :concurrent chemoradiotherapy, advanced hypopharyngeal carcinoma, planned neck dissection