Vol.95 No.1 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 95 No. 1 January 2002
Combined MTX-5FU-CBDCA for the Treatment of Head and Neck Cancer
Takema Sakoda, Yuko Saito, Satoshi Seno, Hideyo Sogo, Hiroki Ikeda,
Satoshi Fujimura, Yoshihiro Dake and Tadao Enomoto
(Japanese Red Cross Society Wakayama Medical Center)
Combination chemotherapy including 5FU and carboplatin (CBDCA) with methotrexate (MTX) and leucovorin (LV) as biochemical modulation was performed on patients with head and neck cancer. A total of 32 patients were treated in the order of MTX, continuous 5FU infusion and LV injection, CBDCA. 24 of the 32 patients were concurrently treated with radiation therapy. Treatment-associated toxicity was significant, including mucositis, myelosuppression and body weight losses, but they were within acceptable limits. The 5-year survival rates calculated using Kaplan-Meyer methods were 41.3％.
Key words : 5FU, head and neck cancer, chemotherapy, carboplatin, biochemical modulation