Vol. 100  No. 6 June  2007

A Case of Synovial Sarcoma of the Larynx

Ryo Ota, Tatsuya Hayashi, Toshihiro Nagato, Yuki Komabayashi, 
Akihiro Katada, Nobuyuki Bando, Takeshi Ogino, Masanobu Imada, 
Naoko Aoki and Yasuaki Harabuchi
(Asahikawa Medical College)

     Synovial sarcoma is a mescenchymal malignancy which accounts for approximately 10% of all soft tissue sarcomas. It usually occurs in the lower limbs of young adults, and only 3% of all synovial sarcomas involve the head and neck region. As the incidence in the head and neck region is very low, only 11 cases with endolaryngeal localization have been reported in the world. We report a case of synovial sarcoma of the larynx.
The patient was a 50-year-old man, complaining of swallowing difficulty. The tumor existed in the left arytenoid and pyriform sinus. Histological diagnosis obtained by biopsy was synovial sarcoma.
As total laryngectomy as a initial treatment was refused, superselective arterial infusion of high-dose cisplatin with concurrent radiotherapy was performed. The effect of the treatment was insufficient after four trials of arterial infusion at one-week intervals and 40 Gy radiation. He finally consented to undergo total laryngectomy. No recurrence has been observed for 18 months after surgery.

Key words : Synovial sarcoma, SYT-SSX gene, superselective arterial infusion chemotherapy, total laryngectomy

第100巻6号 目次   Vol.100 No.6 contents